• Catalog Number:

  E80908-2

• Amount:

  100ul

• Form of Antibody:

  Liquid

• Storage/Stability:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• class="eg_cn_title"Immunogen:

  affinity purified

• Reactivity:

  Mouse

• SwissProtNo:

  Q9Z0E3

• Source:

  Rabbit

• Applications:

  WB: 1:2,000 ICC: 1:500

• Specificity Sensitivity:

  This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to AIRE.

• References:

  1. "Isolation and characterization of the mouse Aire gene."Mittaz L., Rossier C., Heino M., Petersen P., Krohn K.J.E., Gos A., Morris M.A., Kudoh J., Shimizu N., Antonarakis S.E., Scott H.S.Biochem. Biophys. Res. Commun. 255:483-490(1999) 2. "Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity."Koh A.S., Kuo A.J., Park S.Y., Cheung P., Abramson J., Bua D., Carney D., Shoelson S.E., Gozani O., Kingston R.E., Benoist C., Mathis D.Proc. Natl. Acad. Sci. U.S.A. 105:15878-15883(2008) 3. "The autoimmune regulator (AIRE) is a DNA-binding protein."Kumar P.G., Laloraya M., Wang C.-Y., Ruan Q.-G., Davoodi-Semiromi A., Kao K.-J., She J.-X.J. Biol. Chem. 276:41357-41364(2001)

Western blot analysis on 293 cell (A) transfected and (B) none transfected with AIRE gene using anti-AIRE polyclonal antibody.