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Catalog Number:
E1KS2660Amount:
5mgReferences:
Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). Bai F et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52. Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Olson RE et al. Curr Top Med Chem. 2008;8(1):17-33. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. Cook JJ et al. J Neurosci. 2010 May 12;30(19):6743-50. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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